Duration-Dependent Effects of Standardized Ginkgo biloba Extract (EGb 761) in Tinnitus: A Critical Review and Hypothesis for Long-Term Therapeutic Response - by David Charles Kramer
D uration -Dependent Effects of Standardized Ginkgo biloba Extract (EGb 761) in Tinnitus: A Critical Review and Hypothesis for Long-Term Therapeutic Response David Charles Kramer Independent Researcher Abstract Tinnitus affects approximately 10–15% of the global population and remains without a consistently effective curative treatment. The standardized Ginkgo biloba extract EGb 761 has been widely studied as a potential therapeutic intervention; however, clinical findings are frequently described as inconsistent or “mixed.” Notably, most randomized controlled trials (RCTs) evaluating EGb 761 are limited to durations of 8–24 weeks. This study employs a structured narrative review of clinical and mechanistic literature alongside a single-case observational report to examine whether short trial duration may contribute to inconsistent findings. Across reviewed RCTs, EGb 761 demonstrates modest improvements in tinnitus severity, typically ranging from approximately 20–40% reduction on subj...